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Review
. 2017 Jul;22(7):1056-1063.
doi: 10.1016/j.drudis.2017.01.017. Epub 2017 Feb 7.

Emerging RNA Editing Biomarkers Will Foster Drug Development

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Review

Emerging RNA Editing Biomarkers Will Foster Drug Development

Siem van der Laan et al. Drug Discov Today. .

Abstract

Unanticipated adverse drug reactions (ADRs) on the central nervous system are a major cause of clinical attrition and market withdrawal. Current practices for their prospective assessment still lean on extensive analysis of rodent behaviour despite their highly controversial predictive value. Human-derived in vitro models that objectively quantify mechanism-related biomarkers can greatly contribute to better ADR prediction at early developmental stages. Adenosine-to-inosine RNA editing constitutes a physiological cellular process that translates environmental cues by regulating protein function at the synaptic level in health and disease. Robust solutions based on NGS-based quantification of RNA editing biomarkers have emerged to predict the likelihood of treatment-related suicidal ideation and behaviour allowing cost-effective high-throughput drug screening as a strategy for risk mitigation.

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