Effect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trial

J Obstet Gynaecol Res. 2017 May;43(5):887-894. doi: 10.1111/jog.13299. Epub 2017 Feb 11.


Aim: The purpose of study was to assess the effect of zinc sulfate (ZS) supplementation on premenstrual syndrome (PMS) and health-related quality of life (QoL).

Methods: This was a double-blind randomized and placebo-controlled trial using the parallel technique conducted between June 2013 and May 2014. A total of 142 women (age, 20-35 years) with PMS were allocated to either the ZS or placebo group. The women in the intervention group received ZS 220-mg capsules (containing 50 mg elemental zinc) from the 16th day of the menstrual cycle to the second day of the next cycle. Data were collected using the Premenstrual Symptoms Screening Tool (PSST) and 12-item Short-Form Health Survey Questionnaire.

Result: The prevalence of moderate to severe PMS in the ZS group significantly decreased throughout the study period (9.5% in the first, 6% in the second and 2.6% in the third month of the study, P < 0.001), but in the control placebo group this reduction was seen only in the first month of the study (14.2% in the first, 13.7% in the second and 13.5% in the third month, P = 0.08). Also, ZS improved the PSST component scores throughout the study period. The mean scores of QoL in physical and mental components were significantly improved in the ZS intervention group. However, the differences were statistically significant only 3 months after the intervention.

Conclusion: Zinc sulfate, as a simple and inexpensive treatment, was associated with improvement of PMS symptoms and health-related QoL. Additional studies are warranted to confirm these findings.

Keywords: premenstrual syndrome; quality of life; zinc sulfate supplementation.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Astringents / administration & dosage
  • Astringents / pharmacology*
  • Double-Blind Method
  • Female
  • Humans
  • Outcome Assessment, Health Care*
  • Premenstrual Syndrome / drug therapy*
  • Quality of Life
  • Young Adult
  • Zinc Sulfate / administration & dosage
  • Zinc Sulfate / pharmacology*


  • Astringents
  • Zinc Sulfate