Suspected X-linked facial dysmorphia and growth retardation in related Labrador retriever puppies

Vet J. 2017 Feb:220:48-50. doi: 10.1016/j.tvjl.2017.01.004. Epub 2017 Jan 4.


Seven male Labrador retriever puppies from four different litters were identified with a brachycephalic-like face and skull, associated with low birth weight, severe growth retardation, and reduced abilities to crawl and suckle, which were not compatible with survival. Excessive doming of the cranium, brachygnathia superior and inferior, and an abnormally opened fontanelle were found in all affected puppies by computed tomography and at post-mortem examination. Pedigree analysis supported an X-linked recessive mode of inheritance.

Keywords: Brachycephaly; Congenital malformation; Labrador retriever; X-linked inheritance.

MeSH terms

  • Animals
  • Autopsy
  • Developmental Disabilities / diagnostic imaging*
  • Dogs / abnormalities*
  • Face / abnormalities*
  • Male
  • Tomography, X-Ray Computed / veterinary