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Review
. 2012 Aug;15(3):97-102.
doi: 10.1002/j.2205-0140.2012.tb00013.x. Epub 2015 Dec 31.

The development, structure and blood flow within the umbilical cord with particular reference to the venous system

Jacqueline Spurway  1 , Patricia Logan  2 , Sokcheon Pak  3
Affiliations
Free PMC article
Review

The development, structure and blood flow within the umbilical cord with particular reference to the venous system

Jacqueline Spurway et al. Australas J Ultrasound Med. 2012 Aug.
Free PMC article

Abstract

The umbilical cord is a helical and tubular blood conduit connecting the foetus to the placenta. The umbilical cord achieves its final form by the 12th week of gestation and normally contains two arteries and a single vein, all embedded in Wharton's jelly. The structure of the umbilical cord receives only a cursory glance during many obstetric ultrasound examinations: with imaging limited to documenting the number of vessels within the cord and the insertion sites at the foetus and placenta. Extensive research into blood flow characteristics of the umbilical cord arteries has been undertaken and is now widely applied in contemporary ultrasound practice. In contrast, investigation of umbilical vein blood flow is only instigated in instances of foetal compromise when the spectral waveform of the ductus venosus and pulsations in the vein are scrutinised. The current level of ultrasound imaging of the umbilical vein demonstrates a lack of appreciation and knowledge about a structure that is crucial to sustaining foetal life. The goal of this review is to increase awareness of the importance of the umbilical cord. In addition, this review will provide an information platform for undertaking and critically analysing research into the umbilical cord by providing a summary of cord embryology, structure, foetal venous circulation and mechanisms of blood flow within the umbilical cord vein.

Keywords: umbilical cord; umbilical cord vein; venous blood flow.

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Figures

Figure 1
Figure 1
A cross‐sectional image of a postpartum umbilical cord showing the major structures (Hill M. UNSW Embryology. Placenta Histology. [Internet] 2010 [updated 2010 26th May; cited 2011 7th March]; Available from: http://embryology.med.unsw.edu.au/notes/placen‐ta5.htm).
Figure 2
Figure 2
B mode images of a transverse section of the umbilical cord with (a) showing a normal three‐vessel cord and (b) showing a single umbilical artery (←) and vein (→).
Figure 3
Figure 3
Longitudinal images of the umbilical cord with (a) showing paired arteries (←) spiralling around the umbilical vein (→) and (b) showing the vein looping around central coiled arteries.
Figure 4
Figure 4
Pathways for blood flow from the IVC and the ductus venosus (Kiserud T. Physiology of fetal circulation. Semin Fet Neonat Med 2005;10 (6): 493–503).
See this image and copyright information in PMC

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References

    1. Gill RW, Kossoff G, Warren PS, Garrett WJ. Umbilical venous flow in normal and complicated pregnancy. Ultrasound Med Biol 1984; 10 (3): 349–63. - PubMed
    1. Schöni‐Affolter F, Dubuis‐Grieder C, Strauch E. The umbilical cord. [Internet] 2007 [updated 15th October 2007; cited 2012 10th March]; Available from: http://www.embryology.ch/anglais/fplacenta/cordon01.html.
    1. Cochard LR. Netter's Atlas of Human Embryology. 1st ed. New Jersey: Icon Learning Systems; 2002.
    1. Standring S, ed. Gray's Anatomy: The Anatomical Basis of Clinical Practice. 40 ed. Edinburgh: Churchill Livingstone Elsevier; 2008.
    1. Blackburn ST. Maternal, Fetal, & Neonatal Physiology: A Clinical Perspective. 3rd ed. St. Louis: Sanders Elsevier; 2007.

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