A Meta-Analysis on the Diagnostic Performance of Non-Echoplanar Diffusion-Weighted Imaging in Detecting Middle Ear Cholesteatoma: 10 Years On

Otol Neurotol. 2017 Apr;38(4):521-528. doi: 10.1097/MAO.0000000000001353.


Objective: To describe via a meta-analysis of the published literature, the performance of non-echo-planar diffusion weighted imaging (DWI) in detecting middle ear cholesteatoma.

Methodology: A systematic review of the published literature was performed to identify original studies evaluating the diagnostic performance of non-echo-planar DWI in detecting middle ear cholesteatoma. Only studies with surgical correlation were included. A bi-variate meta-analysis and hierarchical summary receiver operating characteristic model was performed.

Results: A total of 26 studies (1,152 patient episodes) were included. Pooled sensitivity and specificity of 0.91 (95% CI: 0.87-0.95) and 0.92 (95% CI: 0.86-0.96), respectively were obtained. Separate subgroup analysis performed for primary cholesteatoma, postoperative cholesteatoma, pediatric cases, and adult cases all showed high sensitivities (range, 0.86-0.93) and specificities (0.88-0.97). There was a statistically significant degree of heterogeneity in terms of sensitivity between all studies (I value 46%) and in the pediatric subgroup (I value 78%). There was no evidence of significant heterogeneity between the specificity measurements.

Conclusions: Non-echo-planar DWI is highly sensitive and specific in detecting cholesteatoma. A large prospective multicentre randomized controlled study could validate the findings and evaluate the cost-effectiveness of DWI as an alternative for second-look surgery (control arm) in managing cases of postoperative cholesteatoma.

Publication types

  • Meta-Analysis
  • Systematic Review

MeSH terms

  • Cholesteatoma, Middle Ear / diagnostic imaging*
  • Cholesteatoma, Middle Ear / surgery
  • Diffusion Magnetic Resonance Imaging / methods*
  • Humans
  • Postoperative Period
  • Prospective Studies
  • Sensitivity and Specificity