Genus Kitasatospora, Taxonomic Features and Diversity of Secondary Metabolites

J Antibiot (Tokyo). 2017 May;70(5):506-513. doi: 10.1038/ja.2017.8. Epub 2017 Feb 15.

Abstract

The genus Kitasatospora was proposed in 1982. Although Kitasatospora strains resemble Streptomyces strains in morphology, they are clearly different in cell-wall composition, as they contain both LL- and meso-diaminopimelic acid. Aerial and submerged spores contain LL-, while vegetative and submerged mycelia contain mainly meso- in their cell walls. Currently, 23 species have been validly proposed. Members of the genus Kitasatospora form a tight cluster and represent a legitimate genus distinct from Streptomyces on the basis of phylogenetic analysis of 16S rRNA gene sequences. A variety of biologically active compounds have been found from Kitasatospora strains and structures of these compounds are extremely diverse. Genome sequences of 15 strains published so far are about 7-9 Mb in size and contain many genes governing secondary metabolites.

Publication types

  • Review

MeSH terms

  • Cell Wall / chemistry
  • Genome, Bacterial
  • Phylogeny
  • RNA, Ribosomal, 16S / genetics*
  • Secondary Metabolism / genetics*
  • Sequence Analysis, RNA
  • Species Specificity
  • Streptomyces / classification
  • Streptomyces / genetics
  • Streptomycetaceae / classification
  • Streptomycetaceae / genetics*
  • Streptomycetaceae / metabolism

Substances

  • RNA, Ribosomal, 16S