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. 2017 Jun;70(6):743-746.
doi: 10.1038/ja.2017.5. Epub 2017 Feb 15.

Two new polyketides from the ascomycete fungus Leptosphaeria sp

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Two new polyketides from the ascomycete fungus Leptosphaeria sp

Jie Lin et al. J Antibiot (Tokyo). 2017 Jun.

Abstract

Leptosphaerins H and I (1 and 2), two new xanthone derivatives, and six known compounds, leptosphaerin F (3), monodictysin B (4), norlichexanthone (5), leptosphaerin D (6), moniliphenone (7) and emodinbianthrone (8) have been isolated from a scale-up fermentation of the ascomycete fungus Leptosphaeria sp. Their structures were primarily elucidated by interpretation of NMR spectroscopic data. The absolute configuration of 1 was assigned using the modified Mosher method, whereas that of C-8a in 2 was determined via the CD data. Compound 6 showed modest cytotoxicity against a panel of three human tumor cell lines.

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