Fusion RNA profiling provides hints on cell of origin of mysterious tumor

Zhongqiu Xie; Hui Li

doi:10.1080/23723556.2016.1263714

Fusion RNA profiling provides hints on cell of origin of mysterious tumor

Mol Cell Oncol. 2016 Nov 29;4(1):e1263714. doi: 10.1080/23723556.2016.1263714. eCollection 2017.

Authors

Zhongqiu Xie¹, Hui Li²

Affiliations

¹ Department of Pathology, University of Virginia , Charlottesville, VA, USA.
² Department of Pathology, University of Virginia, Charlottesville, VA, USA; University of Virginia Cancer Center, Charlottesville, VA, USA.

Abstract

Biological samples can be grouped into separate clusters based on their gene expression profiles. This approach has yielded meaningful biological insights and facilitated biomarker discoveries. Recently, we developed another approach to study connections between biological samples based on their fusion RNA expression. We have used this approach to provide insights into the cell of origin for a mysterious tumor, alveolar rhabdomyosarcoma.

Keywords: Alveolar rhabdomyosarcoma; PAX3-FOXO1; fusion RNA; gene fusion; myogenesis.