The First Biocatalytic Carbon-Silicon Bond Formation

Angew Chem Int Ed Engl. 2017 Mar 13;56(12):3140-3141. doi: 10.1002/anie.201612543. Epub 2017 Feb 15.


Linking two worlds: As a further expansion of the biocatalytic repertoire, carbene insertion into Si-H bonds catalyzed by the heme protein cytochrome c was recently reported. This new biocatalyst holds great promise because it enables the highly selective incorporation of silicon into molecules without prior protection of existing functional groups.

Keywords: biocatalysis; biotransformations; cytochrome P450; enzymes; protein engineering.