Association of polymorphisms rs1800012 in COL1A1 with sports-related tendon and ligament injuries: a meta-analysis

Oncotarget. 2017 Apr 18;8(16):27627-27634. doi: 10.18632/oncotarget.15271.


It has been reported that the single nucleotide polymorphism (SNP) rs1800012 in COL1A1 might be associated with the susceptibility to sports-related tendon and ligament injuries such as ACL injuries, Achilles tendon injuries, shoulder dislocations and tennis elbow. But the data from different studies have been conflicting. Here we attempted to systematically summarize and clarify the association between the SNP and sports-related tendon and ligament injuries risk. Six eligible studies including 933 cases and 1,381 controls were acquired from PubMed, Web Of Science and Cochrane library databases. Significant association was identified in homozygote model (TT versus GG: OR=0.17, 95%CI 0.08-0.35, PH=0.00) and recessive model (TT versus GT/GG: OR=0.21, 95%CI 0.10-0.44, PH=0.00). Our results indicated that COL1A1 rs1800012 polymorphism may be associated with the reduced risk of sports-related tendon or ligament injuries, especially in ACL injuries, and that rare TT may played as a protective role.

Keywords: ACL injury; COL1A1 polymorphism; rs1800012; sports injury; tendon and ligament injury.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Alleles*
  • Athletic Injuries / etiology*
  • Collagen Type I / genetics*
  • Collagen Type I, alpha 1 Chain
  • Disease Susceptibility
  • Genetic Predisposition to Disease*
  • Humans
  • Ligaments / injuries*
  • Odds Ratio
  • Polymorphism, Single Nucleotide*
  • Tendon Injuries / etiology*


  • Collagen Type I
  • Collagen Type I, alpha 1 Chain