New subgroups in the human T cell rearranging V gamma gene locus

EMBO J. 1987 Jul;6(7):1945-50. doi: 10.1002/j.1460-2075.1987.tb02456.x.


Two new V gamma genes in humans are described from rearrangement in T cell lines, which constitute single members of new V gene subgroups of the T-cell rearranging gamma (TRG gamma) locus. These two genes (herein designated as belonging to V gamma III and V gamma IV subgroups) are located between V gamma I/V gamma II subgroups and the constant (C) gamma genes. The existence of these new genes brings the number of different, potentially useable, human TRG V gamma genes to eight (excluding at least five pseudo V gamma genes) and the number of distinct subgroups to four. Polymorphism in the sequence of the V gamma II subgroup gene is also described and rearranged fragment sizes which make possible an unequivocal assignment of a V gamma rearrangement are given. These results extend previous conclusions of the inherited diversity of the human TRG V gamma locus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Cell Line
  • DNA Restriction Enzymes
  • Genes*
  • Humans
  • Molecular Sequence Data
  • Receptors, Antigen, T-Cell / genetics*
  • T-Lymphocytes / immunology*


  • Receptors, Antigen, T-Cell
  • DNA Restriction Enzymes

Associated data

  • GENBANK/X05503
  • GENBANK/X05504
  • GENBANK/X06573
  • GENBANK/X08086