Overexpression of NOTCH-regulated Ankyrin Repeat Protein is associated with papillary thyroid carcinoma progression

Mingdi Zhang; Yiyu Qin; Bin Zuo; Wei Gong; Shenglai Zhang; Yurong Gong; Zhiwei Quan; Bingfeng Chu

doi:10.1371/journal.pone.0167782

Overexpression of NOTCH-regulated Ankyrin Repeat Protein is associated with papillary thyroid carcinoma progression

PLoS One. 2017 Feb 16;12(2):e0167782. doi: 10.1371/journal.pone.0167782. eCollection 2017.

Authors

Mingdi Zhang¹, Yiyu Qin², Bin Zuo³, Wei Gong¹, Shenglai Zhang¹, Yurong Gong¹, Zhiwei Quan¹, Bingfeng Chu¹

Affiliations

¹ Department of General Surgery, Xinhua Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
² Clinical College, Yancheng institute of Health Sciences, Yancheng, Jiangsu, China.
³ Department of Orthopedic Surgery, Xinhua Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.

Abstract

Papillary thyroid cancer (PTC) is one of the endocrine cancers with high clinical and genetic heterogeneity. NOTCH signaling and its downstream NOTCH-Regulated Ankyrin Repeat Protein (NRARP) have been implicated in oncogenesis of many cancers, but the roles in PTCs are less studied. In this study, we show that NRARP is frequently over-expressed in thyroid carcinoma. The over-activation of NRARP is highly and positively correlated with NOTCH genes. Moreover, we find that the expression of NRARP is highly associated with several epithelial mesenchymal transition (EMT) markers and contributes to poor survival outcomes. Therefore, these results indicate that NRARP is an important clinical biomarker in thyroid carcinoma and it promotes EMT induction as well as the progression of PTCs via NOTCH signaling activation.

Publication types

Comparative Study

MeSH terms

Biomarkers, Tumor / genetics
Biomarkers, Tumor / metabolism*
Carcinoma, Papillary / genetics
Carcinoma, Papillary / metabolism
Carcinoma, Papillary / pathology*
Case-Control Studies
Disease Progression
Epithelial-Mesenchymal Transition
Gene Expression Profiling
Humans
Intracellular Signaling Peptides and Proteins
Neoplasm Proteins / genetics
Neoplasm Proteins / metabolism*
Neoplasm Staging
Signal Transduction
Survival Rate
Thyroid Neoplasms / genetics
Thyroid Neoplasms / metabolism
Thyroid Neoplasms / pathology*

Substances

Biomarkers, Tumor
Intracellular Signaling Peptides and Proteins
NRARP protein, human
Neoplasm Proteins

Grants and funding

This work is supported by Shanghai Jiao Tong University School of Medicine scientific research fund project (No. 13XJ22003) to BFC and National Natural Science Foundation of Youth Science Foundation of China (No.81602549) to MDZ, National Natural Science Foundation of Youth Science Foundation of China (No.81501914) to BZ and National Natural Science Foundation of China (No.81272747, No.81572297) to ZWQ. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.