Key Issues in Hymenoptera Venom Allergy: An Update

J Investig Allergol Clin Immunol. 2017;27(1):19-31. doi: 10.18176/jiaci.0123.


In this review, the Hymenoptera Allergy Committee of the SEAIC analyzes the most recent scientific literature addressing problems related to the diagnosis of hymenoptera allergy and to management of venom immunotherapy. Molecular diagnosis and molecular risk profiles are the key areas addressed. The appearance of new species of hymenoptera that are potentially allergenic in Spain and the associated diagnostic and therapeutic problems are also described. Finally, we analyze the issue of mast cell activation syndrome closely related to hymenoptera allergy, which has become a new diagnostic challenge for allergists given its high prevalence in patients with venom anaphylaxis.

Keywords: Hymenoptera; Mastocytosis; Molecular diagnosis; Polistes dominula; Venom immunotherapy.

Publication types

  • Review

MeSH terms

  • Animals
  • Arthropod Venoms / immunology*
  • Arthropod Venoms / therapeutic use
  • Hymenoptera / immunology*
  • Hypersensitivity / diagnosis
  • Hypersensitivity / epidemiology
  • Hypersensitivity / immunology*
  • Hypersensitivity / therapy
  • Immunologic Tests
  • Immunotherapy / methods
  • Insect Bites and Stings / diagnosis
  • Insect Bites and Stings / epidemiology
  • Insect Bites and Stings / immunology*
  • Insect Bites and Stings / therapy
  • Predictive Value of Tests
  • Risk Factors
  • Severity of Illness Index
  • Spain / epidemiology
  • Treatment Outcome


  • Arthropod Venoms