Lipid peroxidation in cell death

Biochem Biophys Res Commun. 2017 Jan 15;482(3):419-425. doi: 10.1016/j.bbrc.2016.10.086. Epub 2017 Feb 3.

Abstract

Disruption of redox homeostasis is a key phenotype of many pathological conditions. Though multiple oxidizing compounds such as hydrogen peroxide are widely recognized as mediators and inducers of oxidative stress, increasingly, attention is focused on the role of lipid hydroperoxides as critical mediators of death and disease. As the main component of cellular membranes, lipids have an indispensible role in maintaining the structural integrity of cells. Excessive oxidation of lipids alters the physical properties of cellular membranes and can cause covalent modification of proteins and nucleic acids. This review discusses the synthesis, toxicity, degradation, and detection of lipid peroxides in biological systems. Additionally, the role of lipid peroxidation is highlighted in cell death and disease, and strategies to control the accumulation of lipid peroxides are discussed.

Keywords: Antioxidant; Ferroptosis; Lipid oxidation; Neurodegeneration; Oxidation; Peroxidation.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Alzheimer Disease / etiology
  • Alzheimer Disease / metabolism
  • Animals
  • Cell Death / drug effects
  • Cell Death / physiology*
  • Humans
  • Lipid Peroxidation / drug effects
  • Lipid Peroxidation / physiology*
  • Lipid Peroxides / metabolism
  • Lipid Peroxides / toxicity
  • Lipoxygenase Inhibitors / pharmacology
  • Metabolic Networks and Pathways
  • Oxidation-Reduction
  • Reducing Agents / pharmacology

Substances

  • Lipid Peroxides
  • Lipoxygenase Inhibitors
  • Reducing Agents