Psoriasis and Comorbid Diseases: Epidemiology

J Am Acad Dermatol. 2017 Mar;76(3):377-390. doi: 10.1016/j.jaad.2016.07.064.


Psoriasis is a common chronic inflammatory disease of the skin that is increasingly being recognized as a systemic inflammatory disorder. Psoriatic arthritis is a well-known comorbidity of psoriasis. A rapidly expanding body of literature in various populations and settings supports additional associations between psoriasis and cardiometabolic diseases, gastrointestinal diseases, kidney disease, malignancy, infection, and mood disorders. The pathogenesis of comorbid disease in patients with psoriasis remains unknown; however, shared inflammatory pathways, cellular mediators, genetic susceptibility, and common risk factors are hypothesized to be contributing elements. As additional psoriasis comorbidities continue to emerge, education of health care providers is essential to ensuring comprehensive medical care for patients with psoriasis.

Keywords: Crohn's disease; cardiovascular disease; chronic kidney disease; comorbidities; depression; infection; lymphoma; metabolic syndrome; nonalcoholic fatty liver disease; psoriasis; psoriatic arthritis.

Publication types

  • Review

MeSH terms

  • Cardiovascular Diseases / epidemiology*
  • Comorbidity
  • Diabetes Mellitus / epidemiology
  • Dyslipidemias / epidemiology
  • Humans
  • Infections / epidemiology
  • Inflammatory Bowel Diseases / epidemiology
  • Liver Diseases / epidemiology
  • Mood Disorders / epidemiology
  • Neoplasms / epidemiology*
  • Obesity / epidemiology
  • Prevalence
  • Psoriasis / epidemiology*
  • Renal Insufficiency, Chronic / epidemiology