The dispersion releaser technology is an effective method for testing drug release from nanosized drug carriers

Eur J Pharm Biopharm. 2017 Jun;115:73-83. doi: 10.1016/j.ejpb.2017.02.006. Epub 2017 Feb 16.


The dispersion releaser (DR) is a dialysis-based setup for the analysis of the drug release from nanosized drug carriers. It is mounted into dissolution apparatus2 of the United States Pharmacopoeia. The present study evaluated the DR technique investigating the drug release of the model compound flurbiprofen from drug solution and from nanoformulations composed of the drug and the polymer materials poly (lactic acid), poly (lactic-co-glycolic acid) or Eudragit®RSPO. The drug loaded nanocarriers ranged in size between 185.9 and 273.6nm and were characterized by a monomodal size distribution (PDI<0.1). The membrane permeability constants of flurbiprofen were calculated and mathematical modeling was applied to obtain the normalized drug release profiles. For comparing the sensitivities of the DR and the dialysis bag technique, the differences in the membrane permeation rates were calculated. Finally, different formulation designs of flurbiprofen were sensitively discriminated using the DR technology. The mechanism of drug release from the nanosized carriers was analyzed by applying two mathematical models described previously, the reciprocal powered time model and the three parameter model.

Keywords: Colloidal drug carriers; Dialysis; Drug release; Flurbiprofen; Mathematical modeling; USP apparatus 2.

MeSH terms

  • Chemistry, Pharmaceutical / methods
  • Drug Carriers / chemistry*
  • Drug Liberation
  • Flurbiprofen / chemistry*
  • Lactic Acid / chemistry
  • Nanoparticles / chemistry*
  • Particle Size
  • Permeability
  • Polyglycolic Acid / chemistry
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Polymethacrylic Acids / chemistry
  • Solubility
  • Technology, Pharmaceutical / methods*


  • Drug Carriers
  • Eudragit RSPO
  • Polymethacrylic Acids
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Polyglycolic Acid
  • Lactic Acid
  • Flurbiprofen