Mechanisms of Cell Polarity-Controlled Epithelial Homeostasis and Immunity in the Intestine

Cold Spring Harb Perspect Biol. 2017 Jul 5;9(7):a027888. doi: 10.1101/cshperspect.a027888.


Intestinal epithelial cell polarity is instrumental to maintain epithelial homeostasis and balance communications between the gut lumen and bodily tissue, thereby controlling the defense against gastrointestinal pathogens and maintenance of immune tolerance to commensal bacteria. In this review, we highlight recent advances with regard to the molecular mechanisms of cell polarity-controlled epithelial homeostasis and immunity in the human intestine.

Publication types

  • Review

MeSH terms

  • Cell Polarity*
  • Epithelial Cells
  • Homeostasis
  • Immunity, Innate
  • Intestines / cytology*
  • Intestines / immunology
  • Microvilli / immunology
  • Models, Theoretical