Stability of Sensory Topographies in Adult Cortex

Trends Cogn Sci. 2017 Mar;21(3):195-204. doi: 10.1016/j.tics.2017.01.002. Epub 2017 Feb 15.

Abstract

Textbooks teach us that the removal of sensory input to sensory cortex, for example, following arm amputation, results in massive reorganisation in the adult brain. In this opinion article, we critically examine evidence for functional reorganisation of sensory cortical representations, focusing on the sequelae of arm amputation on somatosensory topographies. Based on literature from human and non-human primates, we conclude that the cortical representation of the limb remains remarkably stable despite the loss of its main peripheral input. Furthermore, the purportedly massive reorganisation results primarily from the formation or potentiation of new pathways in subcortical structures and does not produce novel functional sensory representations. We discuss the implications of the stability of sensory representations on the development of upper-limb neuroprostheses.

Publication types

  • Review

MeSH terms

  • Adult
  • Amputation*
  • Animals
  • Arm / innervation
  • Arm / surgery
  • Brain Mapping
  • Humans
  • Neuronal Plasticity / physiology*
  • Somatosensory Cortex / physiopathology*