Characteristics and prognosis of Japanese colorectal cancer patients: The BioBank Japan Project

Akiko Tamakoshi; Koshi Nakamura; Shigekazu Ukawa; Emiko Okada; Makoto Hirata; Akiko Nagai; Koichi Matsuda; Yoichiro Kamatani; Kaori Muto; Yutaka Kiyohara; Zentaro Yamagata; Toshiharu Ninomiya; Michiaki Kubo; Yusuke Nakamura; BioBank Japan Cooperative Hospital Group

doi:10.1016/j.je.2016.12.004

Characteristics and prognosis of Japanese colorectal cancer patients: The BioBank Japan Project

J Epidemiol. 2017 Mar;27(3S):S36-S42. doi: 10.1016/j.je.2016.12.004. Epub 2017 Feb 15.

Authors

Collaborators

BioBank Japan Cooperative Hospital Group:
Wataru Ono¹², Hiromasa Harada¹², Shunji Kawamoto¹², Nobuaki Shinozaki¹², Shiro Minami¹³, Takeshi Yamada¹³, Hideyuki Suzuki¹³, Kazuhiro Sakamoto¹⁴, Kazuo Kaneko¹⁴, Shinichi Ohba¹⁴, Satoshi Asai¹⁵, Mitsuhiko Moriyama¹⁵, Yasuo Takahashi¹⁵, Tomoaki Fujioka¹⁶, Wataru Obara¹⁶, Seijiro Mori¹⁷, Hideki Ito¹⁷, Satoshi Nagayama¹⁸, Yoshio Miki¹⁸, Akihide Masumoto¹⁹, Akira Yamada¹⁹, Yasuko Nishizawa²⁰, Ken Kodama²⁰, Tomoharu Shimizu²¹, Shigeyuki Naka²¹, Yukihiro Koretsune²², Mitsugu Sekimoto²², Hiroyuki Kokuto²³

Affiliations

¹ Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan. Electronic address: tamaa@med.hokudai.ac.jp.
² Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
³ Laboratory of Genome Technology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
⁴ Department of Public Policy, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
⁵ Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Laboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
⁶ Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
⁷ Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan.
⁸ Department of Health Sciences, University of Yamanashi, Yamanashi, Japan.
⁹ Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
¹⁰ RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
¹¹ Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, USA.
¹² Tokushukai Hospitals, Japan.
¹³ Nippon Medical School, Japan.
¹⁴ Juntendo University, Japan.
¹⁵ Nihon University, Japan.
¹⁶ Iwate Medical University, Japan.
¹⁷ Tokyo Metropolitan Institute of Gerontology, Japan.
¹⁸ The Cancer Institute Hospital of JFCR, Japan.
¹⁹ Aso Iizuka Hospital, Japan.
²⁰ Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan.
²¹ Shiga University of Medical Science, Japan.
²² National Hospital Organization, Osaka National Hospital, Japan.
²³ Fukujuji Hospital, Japan.

Abstract

Background: Colorectal cancer is the third most common cancer worldwide, and in Japan, it is estimated that about 10% of men and 8% of women will be diagnosed with colorectal cancer during their lifetime.

Methods: We focused on 5864 participants (3699 men and 2165 women) who had colorectal cancer and were registered with BioBank Japan (BBJ) between April 2003 and March 2008. Characteristics of colon and rectal cancer patients were calculated separately. Among the enrolled patients registered in BBJ within 90 days after diagnosis, we also calculated the 5-year cumulative and relative survival rates, and estimated the effect of lifestyle factors on all-cause mortality.

Results: Our participants included younger men than those in the Patient Survey and the Cancer Registry Japan. In more than 95% of cases the histological type was adenocarcinoma both in colon and rectal cancer. Rectal cancer patients tended to eat more meat and less green leafy vegetables compared with colon cancer patients. The 5-year cumulative survival rate was 73.0% (95% CI; 70.1%-75.7%) and the 5-year relative survival rate was 80.6% (77.4%-83.6%), respectively, for colon cancer. For rectal cancer, the rates were 73.3% (69.1%-77.0%) and 80.9% (76.3%-85.0%), in the same order. Lifestyle factors such as consuming less green leafy vegetables, being underweight, smoking, not consuming alcoholic beverages and being physically inactive were found to be related to poor survival.

Conclusions: We described lifestyle characteristics of colorectal cancer patients in BBJ and examined the impacts on subsequent all-cause mortality.

Keywords: Colorectal cancer; Mortality; Prognosis factors.

MeSH terms

Adenocarcinoma / diagnosis
Adenocarcinoma / mortality
Adult
Biological Specimen Banks
Colonic Neoplasms / diagnosis
Colonic Neoplasms / mortality
Colorectal Neoplasms / diagnosis*
Colorectal Neoplasms / mortality*
Female
Humans
Japan / epidemiology
Life Style*
Male
Middle Aged
Prognosis
Rectal Neoplasms / diagnosis
Rectal Neoplasms / mortality
Risk Factors
Survival Rate