The measurement of DLNO and DLCO: A manufacturer's perspective

Respir Physiol Neurobiol. 2017 Jul;241:36-44. doi: 10.1016/j.resp.2017.02.006. Epub 2017 Feb 16.


The simultaneous measurement of the lung transfer factor for carbon monoxide (DLCO) and nitric oxide (DLNO) is now available as a powerful method for studying the alveolar-capillary gas exchange. However, application of the DLNO-CO technique in daily settings is still limited by some technical drawbacks. This paper provides a manufacturer's overview of the measuring principles, technical challenges and current available solutions for implementing the DLNO-CO measurement in to a marketed device. This includes the recent developments in technology for NO sensors, latest findings on NO uptake and new statistical methods.

Keywords: Gas sensor; Lung transfer factor; Medical instrument industry; Nitric oxide.

Publication types

  • Review

MeSH terms

  • Carbon Monoxide / analysis*
  • Equipment Design
  • Humans
  • Nitric Oxide / analysis*
  • Pulmonary Diffusing Capacity / instrumentation*
  • Pulmonary Diffusing Capacity / methods


  • Nitric Oxide
  • Carbon Monoxide