The measurement of DLNO and DLCO: A manufacturer's perspective

X Giraud; N N Le-Dong; K Hogben; J B Martinot

doi:10.1016/j.resp.2017.02.006

The measurement of DLNO and DLCO: A manufacturer's perspective

Respir Physiol Neurobiol. 2017 Jul;241:36-44. doi: 10.1016/j.resp.2017.02.006. Epub 2017 Feb 16.

Authors

X Giraud¹, N N Le-Dong², K Hogben¹, J B Martinot³

Affiliations

¹ Medisoft-MGCD, Sorinnes, Belgium.
² RespiSom Private Research Medical Center, Namur, Belgium. Electronic address: ledongnhatnam@yahoo.com.
³ CHU-UCL Namur, Place Louise Godin 15, 5000, Namur, Belgium.

PMID: 28214604
DOI: 10.1016/j.resp.2017.02.006

Abstract

The simultaneous measurement of the lung transfer factor for carbon monoxide (DLCO) and nitric oxide (DLNO) is now available as a powerful method for studying the alveolar-capillary gas exchange. However, application of the DLNO-CO technique in daily settings is still limited by some technical drawbacks. This paper provides a manufacturer's overview of the measuring principles, technical challenges and current available solutions for implementing the DLNO-CO measurement in to a marketed device. This includes the recent developments in technology for NO sensors, latest findings on NO uptake and new statistical methods.

Keywords: Gas sensor; Lung transfer factor; Medical instrument industry; Nitric oxide.

Publication types

Review

MeSH terms

Carbon Monoxide / analysis*
Equipment Design
Humans
Nitric Oxide / analysis*
Pulmonary Diffusing Capacity / instrumentation*
Pulmonary Diffusing Capacity / methods

Substances

Nitric Oxide
Carbon Monoxide