Targeting IKK and NF-κB for Therapy

Adv Protein Chem Struct Biol. 2017;107:77-115. doi: 10.1016/bs.apcsb.2016.11.006. Epub 2017 Jan 11.

Abstract

In addition to regulating immune responses, the NF-κB family of transcription factors also promotes cellular proliferation and survival. NF-κB and its activating kinase, IKK, have become appealing therapeutic targets because of their critical roles in the progression of many diseases including chronic inflammation and cancer. Here, we discuss the conditions that lead to pathway activation, the effects of constitutive activation, and some of the strategies used to inhibit NF-κB signaling.

Keywords: Cancer; IKK; Inflammation; NF-κB; Therapeutic targets; Transcription factor.

Publication types

  • Review

MeSH terms

  • Cell Proliferation
  • Cell Survival
  • Clinical Trials as Topic
  • Drug Resistance, Neoplasm
  • Humans
  • I-kappa B Kinase / antagonists & inhibitors*
  • Inflammation / drug therapy
  • Inflammation / metabolism
  • NF-kappa B / antagonists & inhibitors*
  • Signal Transduction

Substances

  • NF-kappa B
  • I-kappa B Kinase