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Review
. 2017;104:113-131.
doi: 10.1016/bs.vh.2016.10.002. Epub 2016 Nov 29.

Emergent Role of Coronin-1a in Neuronal Signaling

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Free PMC article
Review

Emergent Role of Coronin-1a in Neuronal Signaling

M Martorella et al. Vitam Horm. .
Free PMC article

Abstract

The Coronin family of proteins were first noted for their role in pathogen-host interactions and for modulating actin dynamics. Recently, however, Coronins have been found in a greater variety of cell types, and novel roles for the Coronins within the nervous system have been discovered. In the immune system, Coronin-1a enables Mycobacterium tuberculosis to evade lysosomal destruction. This activity appears to be analogous to protection of the NGF-TrkA signaling endosome during sympathetic nervous system development that is required for survival signaling. Similarly, others have implicated Coronin-1a in GPCR signaling during the formation of excitatory connections in the central nervous system. Its role in multiple signaling pathways suggests that it may influence cross talk between key pathways (TrkA, GPCRs) during neurodevelopment. Here, we review the role of Coronin-1a in neural development and function.

Keywords: Coro1a; Coronin; NGF; Nerve growth factor; Neurodevelopment; Neurotrophins; Receptor tyrosine kinase; Sympathetic nervous system; TrkA.

Figures

Fig. 1
Fig. 1
(A) Structural characteristics of each Coronin family subtype. Highlighted are the conserved phosphorylation sites and high-affinity F-actin binding site (R30) on type I Coronins. (B) Coronin oligomerization occurs via coiled-coil domain interactions. Phosphorylation disrupts coiled-coil interactions and induces monomerization.
Fig. 2
Fig. 2
Schematic of the role of Coronin-1a in NGF–TrkA and beta-adrenergic GPCR signaling pathways in neurons. It is not known whether activation of PKC by Coronin-1a results in a negative feedback loop in which PKC downregulates Coronin-1a activity.
Fig. 3
Fig. 3
Coronin-1a endows the NGF–TrkA signaling endosome with enhanced signaling and trafficking capabilities. By associating with Coronin-1a, the NGF–TrkA signaling endosome can undergo transcytosis and prolong NGF–TrkA signaling.
Fig. 4
Fig. 4
(A) Upon initially encountering a target organ, NGF concentrations are low and NGF-induced genes are not yet expressed. This marks a “transition window,” in which low NGF availability enhances axon growth and branching via PI3K signaling. (B) High NGF induces Coronin-1a expression, and PI3K signaling is dampened. Axon growth and branching slows.

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