Protective effects of short-term dietary restriction in surgical stress and chemotherapy

Ageing Res Rev. 2017 Oct;39:68-77. doi: 10.1016/j.arr.2017.02.001. Epub 2017 Feb 20.


Reduced caloric intake including fasting, as well as the dietary composition or the timing of food intake, impact longevity, likely through a modification in the onset or the severity of chronic aging-related diseases such as cancer. As with pre- and post-operative dietary recommendations, evidence-based nutritional advice from healthcare professionals during and after cancer treatment is often vague or conflicting. We hypothesize that preventive dietary recommendations can help in the context of both chronic cancer treatment efficacy and the avoidance of development of secondary malignancies, as well as in the context of protection from the acute stress of surgery. In this perspective review, we will discuss the latest findings on the potential role of short-term dietary restriction in cancer treatment and improvement of surgical outcome.

Keywords: Calorie restriction; Cancer; Chemotherapy; Dietary restriction; Fasting; Surgery.

Publication types

  • Review

MeSH terms

  • Animals
  • Caloric Restriction*
  • Diet
  • Energy Intake
  • Fasting / physiology*
  • Humans
  • Longevity
  • Neoplasms / prevention & control*
  • Preoperative Care*
  • Signal Transduction
  • Stress, Physiological*