Abstract
Administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, 20 micrograms/kg) to pregnant C57BL/6J mice (on day 10) resulted in 62% fetuses with cleft palate per litter without any observable maternal toxicity. In contrast, Aroclor 1254 administered at a dose of 750 mumol/kg was not teratogenic. Cotreatment of the pregnant mice with both Aroclor 1254 (244 mg/kg) and 2,3,7,8-TCDD (20 micrograms/kg) resulted in an 8.2% incidence of cleft palate per litter. In contrast, Aroclor 1254 did not afford any protection from the teratogenicity of dexamethasone in C57BL/6J mice. Previous studies have shown that Aroclor 1254 can act as a partial antagonist of the microsomal enzyme induction and immunotoxic effects of 2,3,7,8-TCDD in C57BL/6J mice and this paper demonstrates that the commercial polychlorinated biphenyl mixture also antagonizes 2,3,7,8-TCDD-mediated teratogenicity in this strain of mice.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Abnormalities, Drug-Induced / etiology*
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Abnormalities, Drug-Induced / prevention & control
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Animals
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Aroclors / pharmacology*
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Chlorodiphenyl (54% Chlorine)
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Cleft Palate / chemically induced*
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Cleft Palate / prevention & control
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Dexamethasone / toxicity
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Dioxins / antagonists & inhibitors*
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Drug Interactions
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Enzyme Induction / drug effects
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Female
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Mice
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Mice, Inbred C57BL
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Microsomes, Liver / drug effects
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Microsomes, Liver / enzymology
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Polychlorinated Biphenyls / pharmacology*
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Polychlorinated Dibenzodioxins / antagonists & inhibitors*
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Polychlorinated Dibenzodioxins / toxicity
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Pregnancy
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Receptors, Aryl Hydrocarbon
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Receptors, Drug / drug effects
Substances
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Aroclors
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Dioxins
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Polychlorinated Dibenzodioxins
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Receptors, Aryl Hydrocarbon
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Receptors, Drug
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Chlorodiphenyl (54% Chlorine)
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Dexamethasone
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Polychlorinated Biphenyls