Blood metal ion concentrations in metal-on-metal total hip arthroplasty

Eur J Orthop Surg Traumatol. 2017 May;27(4):527-532. doi: 10.1007/s00590-017-1931-y. Epub 2017 Feb 20.

Abstract

Introduction: The hip placement with a metal-on-metal (MOM) bearing has been used for both surface replacement and total hip arthroplasty (THA). Use of MOM bearing for hip replacement reduces the wear compared to conventional bearings.

Methods: We prospectively assessed 30 patients who underwent unilateral MOM THA. A control group of 30 patients who underwent metal-on-polyethylene THA using the implants as the other group, except for bearing, were accessed. Blood samples were collected preoperatively and at 3- , 6- , 9- , 12- , 15- , 18- , and 24-month intervals. Changes in mean blood metal ion concentration were compared between the MOM and metal-on-polyethylene groups.

Results: A statistically significant positive correlation was observed between blood cobalt and chromium concentrations in all of the patients. The mean blood ion concentrations of the MOM were significantly higher than those of the metal-on-polyethylene. A statistically significant negative correlation was found between maximum blood cobalt concentration and cup version angle. The maximum blood chromium concentrations in the patients who had larger cup version angles were more likely to decrease.

Conclusions: We considered that cup version angle is one of the factors that have the greatest effect on blood metal ion concentration, and the target cup version angle that did not induce an increase in blood metal ion concentrations was approximately 20°.

Keywords: Angle; Cup version angle; Ions; Metal; Metal-on-metal; Total hip arthroplasty.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Arthroplasty, Replacement, Hip / adverse effects
  • Arthroplasty, Replacement, Hip / methods*
  • Blood Chemical Analysis
  • Case-Control Studies
  • Chromium / blood*
  • Cobalt / blood*
  • Female
  • Follow-Up Studies
  • Hip Prosthesis*
  • Humans
  • Male
  • Metal-on-Metal Joint Prostheses / adverse effects*
  • Middle Aged
  • Prospective Studies
  • Prosthesis Design
  • Reference Values
  • Risk Assessment

Substances

  • Chromium
  • Cobalt