Immunoprofiling as a predictor of patient's response to cancer therapy-promises and challenges

Curr Opin Immunol. 2017 Apr:45:60-72. doi: 10.1016/j.coi.2017.01.005. Epub 2017 Feb 20.

Abstract

Immune cell infiltration is common to many tumors and has been recognized by pathologists for more than 100 years. The application of digital imaging and objective assessment software allowed a concise determination of the type and quantity of immune cells and their location relative to the tumor and, in the case of colon cancer, characterized overall survival better than AJCC TNM staging. Subsequently, expression of PD-L1, by 50% or more tumor cells, identified NSCLC patients with double the response rate to anti-PD-1. Soon, automated staining methods will improve reproducibility of multiplex staining and allow for CLIA standards so that multiplex staining can be used to make clinical decisions. Ultimately, machine-learning algorithms will help interpret data from tissue images and lead to improved delivery of precision medicine.

Publication types

  • Review

MeSH terms

  • Animals
  • B7-H1 Antigen / immunology*
  • Carcinoma, Non-Small-Cell Lung / immunology*
  • Carcinoma, Non-Small-Cell Lung / pathology
  • Carcinoma, Non-Small-Cell Lung / therapy
  • Colonic Neoplasms / immunology*
  • Colonic Neoplasms / pathology
  • Colonic Neoplasms / therapy
  • Gene Expression Profiling*
  • Gene Expression Regulation, Neoplastic / immunology*
  • Humans
  • Lung Neoplasms / immunology*
  • Lung Neoplasms / pathology
  • Lung Neoplasms / therapy
  • Neoplasm Proteins / immunology*

Substances

  • B7-H1 Antigen
  • CD274 protein, human
  • Neoplasm Proteins