Increased static and decreased capacity oxidation-reduction potentials in plasma are predictive of metabolic syndrome

Redox Biol. 2017 Aug:12:121-128. doi: 10.1016/j.redox.2017.02.010. Epub 2017 Feb 14.


Electric conductivity in plasma is the balance between oxidized and reduced molecules (static Oxidation-Reduction Potential, sORP) and the amount of readily oxidizable molecules (capacity ORP, cORP). Adults with metabolic syndrome (MetS) have increased inflammation, dyslipidemia and oxidative stress; therefore, participants with MetS were hypothesized to have higher plasma sORP and lower cORP than those measures in healthy adults. Heparin-anticoagulated plasma from healthy and age- and gender-matched individuals with MetS (BMI: 22.6±0.7 vs. 37.7±3.0kg/m2, respectively) was collected in the fasting state at 0, 24, 48, and 72h during each of four separate interventions in a clinical trial. At baseline, plasma sORP was 12.4% higher (P=0.007), while cORP values were less than half (41.1%, P=0.001) in those with MetS compared with healthy participants. An sORP >140mV detected MetS with 90% sensitivity and 80% specificity, while a cORP <0.50μC detected MetS with 80% sensitivity and 100% specificity. sORP and cORP values in participants with MetS compared with healthy adults were linked to differences in waist circumference and BMI; in plasma markers of dyslipidemia (triglycerides, HDL-cholesterol, and oxidized LDL-cholesterol) and inflammation (C-reactive protein, IL-10); as well as with urinary markers of lipid peroxidation (e.g., 2,3-dinor-5,6-dihydro-8-iso-PGF; 2,3-dinor-8-iso-PGF). Higher sORP values are a robust indicator of metabolic stress, while lower cORP values act as an indicator of decreased metabolic resilience.

Keywords: Dyslipidemia; Inflammation; Isoprostanes; Lipid peroxidation; Metabolic syndrome; Obesity; Oxidation-reduction potential.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers / blood*
  • C-Reactive Protein / metabolism
  • Cholesterol, HDL / blood
  • Cross-Over Studies
  • Double-Blind Method
  • Female
  • Humans
  • Interleukin-10 / blood
  • Lipoproteins, LDL / blood
  • Male
  • Metabolic Syndrome / blood*
  • Oxidation-Reduction*
  • Triglycerides / blood
  • Young Adult


  • Biomarkers
  • Cholesterol, HDL
  • IL10 protein, human
  • Lipoproteins, LDL
  • Triglycerides
  • Interleukin-10
  • C-Reactive Protein