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Review
. 2017 Feb 21;135(8):717-719.
doi: 10.1161/CIRCULATIONAHA.116.025795.

Ejection Fraction: Misunderstood and Overrated (Changing the Paradigm in Categorizing Heart Failure)

Affiliations
Review

Ejection Fraction: Misunderstood and Overrated (Changing the Paradigm in Categorizing Heart Failure)

Marvin A Konstam et al. Circulation. .
No abstract available

Keywords: cardiac remodeling; ejection fraction; heart failure.

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Figures

Figure 1
Figure 1
Schematics of changes in P-V (Pressure-Volume) loops of the LV (left ventricle) and in SV (stroke volume) and EF (ejection fraction). The upper panels indicate the effects of increases in preload (A) and afterload (B) shown in red vs. control P-V curves in black. Data to support such changes were published in J. Physiol. 48: 465, 1914 by Patterson, Piper, and Starling. The lower panels indicate the effects of cardiac remodeling in heart failure with hypertrophic cardiomyopathy in (C) and dilated cardiomyopathy in (D) with reduced and increased EDVs (end-diastolic volumes) respectively.

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References

    1. Eaton LW, Weiss JL, Bulkley BH, Garrison JB, Weisfeldt ML. Regional cardiac dilatation after acute myocardial infarction: recognition by two dimensional echocardiography. N Engl J Med. 1979;300:57–62. - PubMed
    1. Konstam MA, Kramer DG, Patel AR, Maron MS, Udelson JE. Left ventricular remodeling in heart failure: current concepts in clinical significance and assessment. JACC Cardiovasc Imaging. 2011;4:98–108. - PubMed
    1. Paulus WJ, Tschöpe C. A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. J Am Coll Cardiol. 2013;62:263–71. - PubMed
    1. Kramer DG, Trikalinos TA, Kent DM, Antonopoulos GV, Konstam MA, Udelson JE. Quantitative evaluation of drug or device effects on ventricular remodeling as predictors of therapeutic effects on mortality in patients with heart failure and reduced ejection fraction: a meta-analytic approach. J Am Coll Cardiol. 2010;56:392–406. - PMC - PubMed
    1. Aijaz B, Ammar KA, Lopez-Jimenez F, Redfield MM, Jacobsen SJ, Rodeheffer RJ. Abnormal cardiac structure and function in the metabolic syndrome: a population-based study. Mayo Clin Proc. 2008;83:1350–7. - PMC - PubMed

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