Effect of Serum Albumin on the Prognosis of Elderly Patients With Stage 3-4 Chronic Kidney Disease

Int Urol Nephrol. 2017 May;49(5):859-865. doi: 10.1007/s11255-017-1542-x. Epub 2017 Feb 21.


Objective: To investigate the influence of serum albumin on the prognosis of elderly patients with stage 3-4 chronic kidney disease (CKD).

Methods: From July 2013 to November 2015, elderly CKD patients (≥60 years), with eGFR ≥15 mL/min/1.73 m2 and <60 mL/min/1.73 m2, with CKD stage 3-4 in the geriatric nephrology clinic were enrolled. General information and underlying diseases were recorded. Laboratory indices were evaluated. Composite endpoint events (CEE) including renal endpoint events, cardiocerebral vascular endpoint events, and death were elucidated. Based on the ROC curves, the patients were divided into lower and higher serum albumin groups (<42.5 and ≥42.5 g/L).

Results: The occurrence of CEEs was significantly higher in lower serum albumin group than those in the higher group. Also, the patients in the higher group were significantly younger with lower urinary protein, blood urea, brain natriuretic peptide, and cystatin C than those in the lower serum albumin group. Contrastingly, hemoglobin, total serum protein, serum calcium, and superoxide dismutase were remarkably higher. The composite endpoints of multifactor logistic regression analysis indicated that as the serum albumin is increased by every 1 g/L, the probability of CEEs would reduce 14.8%, and the risk occurrence rate of the lower serum albumin group was 4.739 fold than the higher group.

Conclusion: The results suggest that patients with higher serum albumin had a better prognosis than those with lower serum albumin. The low level was an independent risk factor influencing the prognosis of elderly patients in stage 3-4 CKD.

Keywords: CKD; Elderly patients; Prognosis; Serum albumin.

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Biomarkers / blood
  • China
  • Cohort Studies
  • Disease Progression
  • Female
  • Geriatric Assessment / methods*
  • Glomerular Filtration Rate / physiology
  • Humans
  • Kidney Function Tests
  • Logistic Models
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Prognosis
  • Renal Insufficiency, Chronic / blood*
  • Renal Insufficiency, Chronic / diagnosis*
  • Renal Insufficiency, Chronic / mortality
  • Retrospective Studies
  • Risk Assessment
  • Serum Albumin / analysis*
  • Severity of Illness Index
  • Sex Factors
  • Survival Rate


  • Biomarkers
  • Serum Albumin