Neural correlates of lexical decisions in Parkinson's disease revealed with multivariate extraction of cortico-subthalamic interactions

Clin Neurophysiol. 2017 Apr;128(4):538-548. doi: 10.1016/j.clinph.2016.12.026. Epub 2017 Jan 17.

Abstract

Objective: Neural interactions between cortex and basal ganglia are pivotal for sensorimotor processing. Specifically, coherency between cortex and subthalamic structures is a frequently studied phenomenon in patients with Parkinson's disease. However, it is unknown whether cortico-subthalamic coherency might also relate to cognitive aspects of task performance, e.g., language processing. Furthermore, standard coherency studies are challenged by how to efficiently handle multi-channel recordings.

Methods: In eight patients with Parkinson's disease treated with deep brain stimulation, simultaneous recordings of surface electroencephalography and deep local field potentials were obtained from bilateral subthalamic nuclei, during performing a lexical decision task. A recent multivariate coherency measure (maximized imaginary part of coherency, MIC) was applied, simultaneously accounting for multi-channel recordings.

Results: Cortico-subthalamic synchronization (MIC) in 14-35Hz oscillations positively correlated with accuracy in lexical decisions across patients, but not in 7-13Hz oscillations. In contrast to multivariate MIC, no significant correlation was obtained when extracting cortico-subthalamic synchronization by "standard" bivariate coherency.

Conclusions: Cortico-subthalamic synchronization may relate to non-motor aspects of task performance, here reflected in lexical accuracy.

Significance: The results tentatively suggest the relevance of cortico-subthalamic interactions for lexical decisions. Multivariate coherency might be effective to extract neural synchronization from multi-channel recordings.

Keywords: Basal ganglia; Beta; Deep brain stimulation; Language; Oscillations; STN.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Basal Ganglia / physiopathology
  • Case-Control Studies
  • Cerebral Cortex / physiopathology
  • Cortical Synchronization*
  • Decision Making*
  • Deep Brain Stimulation
  • Female
  • Humans
  • Language*
  • Male
  • Middle Aged
  • Parkinson Disease / physiopathology*