Synaptonemal complex and crossing-over: structural support or interference?

Heredity (Edinb). 1978 Oct;41(2):233-37. doi: 10.1038/hdy.1978.92.


Positive cross-over interference is attributed to the prevention of crossing-over by the growing synaptonemal complex. This conjecture is based on a report in the literature that the selection of prospective cross-over sites may actually precede a proper synapsis of homologous chromosomes during meiotic prophase. A genetic test of this notion is suggested using a properly marked trisomic configuration, applicable to a variety of organisms.

MeSH terms

  • Animals
  • Crossing Over, Genetic*
  • Drosophila / genetics
  • Meiosis*
  • Models, Biological*
  • Mutation
  • Recombination, Genetic