Immediately Functioning Grafts from Brain-Dead Donors Treated with Extracorporeal Membrane Oxygenation

Exp Clin Transplant. 2019 Jun;17(3):404-407. doi: 10.6002/ect.2016.0369. Epub 2017 Feb 23.

Abstract

A brain-dead donor experienced repeated cardiac arrests followed by severe hypotension requiring multiple vasoactive agents. These events were associated with severe lactic acidosis and dysregulated kidney function in the donor. A 10-hour treatment with extracorporeal membranous oxygenation was instituted, which was able to hemodynamically stabilize the donor. This treatment protocol resulted in the procurement of 2 viable kidney grafts transplanted into 2 recipients, who had immediate kidney graft function and excellent serum creatinine levels upon hospital discharge. These results are all the more significant considering that both cases involved long cold ischemia times, and one of the recipients had diabetes and was receiving his second kidney graft.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Brain Death*
  • Extracorporeal Membrane Oxygenation*
  • Humans
  • Kidney / physiology*
  • Kidney Transplantation*
  • Male
  • Recovery of Function
  • Time Factors
  • Tissue Donors