Abstract
We used an in situ exonuclease III protection technique (C. Wu, Nature [London] 309:229, 1984) to analyze protein-DNA interactions at a dioxin-responsive enhancer. Our results imply that the 2,3,7,8-tetrachlorodibenzo-p-dioxin-receptor complex interacts with the dioxin-responsive enhancer to activate transcription of the cytochrome P1-450 gene.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Base Sequence
-
Chromatin / drug effects
-
Chromatin / ultrastructure
-
Cytochrome P-450 Enzyme System / genetics*
-
Deoxyribonucleoproteins / metabolism*
-
Dioxins / pharmacology*
-
Enhancer Elements, Genetic / drug effects*
-
Exodeoxyribonucleases
-
Genes / drug effects*
-
Genes, Regulator / drug effects
-
Liver Neoplasms, Experimental / metabolism
-
Mice
-
Polychlorinated Dibenzodioxins / pharmacology*
-
Receptors, Aryl Hydrocarbon
-
Receptors, Drug / metabolism
-
Transcription, Genetic
Substances
-
Chromatin
-
Deoxyribonucleoproteins
-
Dioxins
-
Polychlorinated Dibenzodioxins
-
Receptors, Aryl Hydrocarbon
-
Receptors, Drug
-
Cytochrome P-450 Enzyme System
-
Exodeoxyribonucleases
-
exodeoxyribonuclease III