Umbilical cord stem cells in the treatment of corneal disease

Mohammed Ziaei; Jie Zhang; Dipika V Patel; Charles N J McGhee

doi:10.1016/j.survophthal.2017.02.002

Umbilical cord stem cells in the treatment of corneal disease

Surv Ophthalmol. 2017 Nov-Dec;62(6):803-815. doi: 10.1016/j.survophthal.2017.02.002. Epub 2017 Feb 21.

Authors

Mohammed Ziaei¹, Jie Zhang¹, Dipika V Patel¹, Charles N J McGhee²

Affiliations

¹ Faculty of Medical and Health Sciences, Department of Ophthalmology, New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand.
² Faculty of Medical and Health Sciences, Department of Ophthalmology, New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand. Electronic address: c.mcghee@auckland.ac.nz.

PMID: 28232219
DOI: 10.1016/j.survophthal.2017.02.002

Abstract

Stem cells are capable of giving rise to progenies with specific functional and morphological traits and, in recent years, extraordinary scientific advances have initiated an era of hope for clinical regenerative strategies and tissue engineering applications. We appraise the potential benefits of human umbilical cord-derived stem cell therapy and consider current approaches to utilize these stem cells in corneal epithelial, stromal, and endothelial disorders.

Keywords: cornea; human umbilical cord stem cells; mesenchymal stem cells; stem cell therapy; tissue regeneration; transplantation.

Publication types

Review

MeSH terms

Corneal Diseases / surgery*
Humans
Mesenchymal Stem Cell Transplantation / methods
Mesenchymal Stem Cells
Stem Cell Transplantation / methods*
Stem Cells / cytology*
Tissue Engineering / methods
Umbilical Cord / cytology*