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. 2017 Feb 24;49(3):323-324.
doi: 10.1038/ng.3798.

Untangling the Genetics From the Epigenetics in Pancreatic Cancer Metastasis

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Untangling the Genetics From the Epigenetics in Pancreatic Cancer Metastasis

Christopher R Vakoc et al. Nat Genet. .

Abstract

Comparative genomic analyses of primary tumors and metastases within individuals with pancreatic cancer have exposed the complex clonal dynamics that underlie the dissemination of cancer cells to distant sites. Recent studies implicate non-genetic mechanisms in this process, particularly fluctuations in chromatin states and metabolism, which can endow rare cells within a primary tumor with metastatic potential.

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