Orthogonal near-infrared upconversion co-regulated site-specific O2 delivery and photodynamic therapy for hypoxia tumor by using red blood cell microcarriers

Biomaterials. 2017 May:125:90-100. doi: 10.1016/j.biomaterials.2017.02.017. Epub 2017 Feb 14.

Abstract

Pre-existing hypoxia in tumors can result in an inadequate oxygen supply during photodynamic therapy (PDT), which in turn hampers photodynamic efficacy. To overcome this problem, we developed an orthogonal near-infrared upconversion controlled red blood cell (RBC) microcarriers to selectively deliver O2 in hypoxia area. Moreover, this RBC microcarriers are able to overcome a series of complex biological barriers which include transporting across the inflamed endothelium, evading mononuclear phagocyte system, reducing reticuloendothelial system uptake. Based on these abilities, RBC microcarriers have efficient tumors accumulation and are capable of delivery a large amount of O2 for PDT under near-infrared (NIR) irradiation to realize effective solid tumor eradication.

Keywords: Biological barriers; Hypoxia; Photodynamic therapy; Upconversion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Capsules / chemistry
  • Capsules / radiation effects
  • Combined Modality Therapy / methods
  • Delayed-Action Preparations / administration & dosage*
  • Erythrocyte Transfusion / methods*
  • Erythrocytes / chemistry
  • Erythrocytes / drug effects
  • Erythrocytes / metabolism*
  • Infrared Rays
  • Mice
  • Mice, Inbred BALB C
  • Neoplasms, Experimental / drug therapy*
  • Neoplasms, Experimental / pathology
  • Oxygen / administration & dosage*
  • Oxygen / blood
  • Photochemotherapy / methods*
  • Treatment Outcome
  • Tumor Hypoxia / drug effects*

Substances

  • Capsules
  • Delayed-Action Preparations
  • Oxygen