Mechano-sensitive regulation of gene expression during the embryonic development

Genesis. 2017 Apr;55(4). doi: 10.1002/dvg.23026. Epub 2017 Mar 17.


Cell movements during embryogenesis produce mechanical tensions that shape the embryo and can also regulate gene expression, thereby affecting cell differentiation. Increasing evidence indicates that mechanosensitive regulation of gene expression plays important roles during embryogenesis by coupling the processes of morphogenesis and differentiation. However, the molecular mechanisms of this phenomenon remain poorly understood. This review focuses on the molecular mechanisms that "translate" mechanical stimuli into gene expression.

Keywords: convergent extension; embryogenesis; gene expression; mechanical stress; mechanotransduction.

Publication types

  • Review

MeSH terms

  • Animals
  • Embryonic Development*
  • Gene Expression Regulation, Developmental*
  • Humans
  • Mechanotransduction, Cellular*
  • Transcriptional Activation