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, 22 (3), 377-80

Detection of Varicella-Zoster Virus Nucleic Acid in Neurons of Normal Human Thoracic Ganglia

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Detection of Varicella-Zoster Virus Nucleic Acid in Neurons of Normal Human Thoracic Ganglia

D H Gilden et al. Ann Neurol.

Abstract

Tissue sections from four normal human thoracic ganglia were hybridized in situ with a varicella-zoster virus-RNA probe. Varicella-zoster virus was detected in two of four ganglia, localized exclusively in neurons. The detection of latent varicella-zoster virus genetic material in thoracic ganglia provides further evidence of varicella-zoster virus latency at multiple levels of the human neuraxis and supports the notion that the neuron is the primary site of herpesvirus latency.

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