MicroRNAs in Lung Development and Disease

Dustin Ameis; Naghmeh Khoshgoo; Barbara M Iwasiow; Phillip Snarr; Richard Keijzer

doi:10.1016/j.prrv.2016.12.002

MicroRNAs in Lung Development and Disease

Paediatr Respir Rev. 2017 Mar:22:38-43. doi: 10.1016/j.prrv.2016.12.002. Epub 2016 Dec 14.

Authors

Dustin Ameis¹, Naghmeh Khoshgoo¹, Barbara M Iwasiow¹, Phillip Snarr¹, Richard Keijzer²

Affiliations

¹ Departments of Surgery, Pediatrics and Child Health and Physiology and Pathophysiology, University of Manitoba, and The Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
² Departments of Surgery, Pediatrics and Child Health and Physiology and Pathophysiology, University of Manitoba, and The Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada. Electronic address: richardkeijzer@gmail.com.

PMID: 28237418
DOI: 10.1016/j.prrv.2016.12.002

Abstract

MicroRNAs (miRNAs) are small (∼22 nucleotides), non-coding RNA molecules that regulate gene expression post-transcriptionally by inhibiting target mRNAs. Research into the roles of miRNAs in lung development and disease is at the early stages. In this review, we discuss the role of miRNAs in pediatric respiratory disease, including cystic fibrosis, asthma, and bronchopulmonary dysplasia.

Keywords: MicroRNAs; asthma; bronchopulmonary dysplasia; cystic fibrosis; gene expression; lung development.

Publication types

Review

MeSH terms

Animals
Asthma / genetics
Bronchopulmonary Dysplasia / genetics
Cystic Fibrosis / genetics
Gene Expression
Gene Expression Regulation, Developmental
Humans
Lung / embryology*
Lung / growth & development
Lung Diseases / genetics*
MicroRNAs / genetics*

Substances

MicroRNAs