Allodynia Lowering Induced by Cannabinoids and Endocannabinoids (ALICE)

Pharmacol Res. 2017 May;119:272-277. doi: 10.1016/j.phrs.2017.02.019. Epub 2017 Feb 22.

Abstract

Neuropathic pain is a neurological disorder that strongly affects the quality of life of patients. The molecular and cellular mechanisms at the basis of the neuropathic pain establishment still need to be clarified. Among the neuromodulators that play a role in the pathological pain pathways, endocannabinoids could be deeply involved in both neuronal and non-neuronal mechanisms responsible for the appearance of tactile allodynia. Indeed, the function and dysfunction of this complex system in the molecular and cellular mechanisms of chronic pain induction and maintenance have been widely studied over the last two decades. In this review article, we highlighted the possible modulation of the endocannabinoid system in the neuronal, glial and microglial modulation in neuropathic pain treatment.

Keywords: Astrocytes; Cannabinoid system; Endocannabinoids; Microglia; Neuropathic pain.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics / pharmacology
  • Analgesics / therapeutic use*
  • Animals
  • Astrocytes / drug effects
  • Astrocytes / metabolism
  • Astrocytes / pathology
  • Cannabinoid Receptor Modulators / pharmacology
  • Cannabinoid Receptor Modulators / therapeutic use
  • Cannabinoids / metabolism*
  • Endocannabinoids / metabolism*
  • Humans
  • Hyperalgesia / drug therapy*
  • Hyperalgesia / metabolism
  • Hyperalgesia / pathology
  • Molecular Targeted Therapy / methods
  • Neuralgia / drug therapy*
  • Neuralgia / metabolism
  • Neuralgia / pathology
  • Neuroglia / drug effects
  • Neuroglia / metabolism
  • Neuroglia / pathology

Substances

  • Analgesics
  • Cannabinoid Receptor Modulators
  • Cannabinoids
  • Endocannabinoids