Increased levels of anti-phosphatidylcholine and anti-phosphatidylethanolamine antibodies in pediatric patients with cerebral infarction

Brain Dev. 2017 Jun;39(6):542-546. doi: 10.1016/j.braindev.2017.01.010. Epub 2017 Feb 24.

Abstract

Cerebral infarction in children is rare and often occurs secondary to moyamoya disease, hereditary coagulopathies, vasculitis, antiphospholipid antibody syndrome, heart disease, mitochondrial disease. However, in some cases, the causes of cerebral infarction is unknown. In this study, we detected increased levels of serum anti-phosphatidylcholine and anti-phosphatidylethanolamine IgG antibodies in three pediatric patients with cerebral infarction whose primary disorders are unknown by routine examination. For the five disease control patients of cerebral infarction due to other primary disorders, there was no such increase in these antibodies levels. Phosphatidylcholine and phosphatidylethanolamine are major components of the phospholipids of vascular endothelial cells, while cardiolipin is a minor component. Anti-phosphatidylcholine and anti-phosphatidylethanolamine antibodies, as well as anti-cardiolipin antibody, might also be risk factors with cerebral infarction.

Keywords: Antiphosphatidylcholine antibody; Antiphosphatidylethanolamine antibody; Cerebral infarction.

Publication types

  • Case Reports

MeSH terms

  • Autoantibodies / metabolism*
  • Cerebral Infarction / blood
  • Cerebral Infarction / diagnostic imaging
  • Cerebral Infarction / immunology*
  • Child, Preschool
  • Female
  • Follow-Up Studies
  • Humans
  • Infant
  • Infant, Newborn
  • Magnetic Resonance Angiography
  • Magnetic Resonance Imaging
  • Phosphatidylcholines / immunology*
  • Phosphatidylethanolamines / immunology*

Substances

  • Autoantibodies
  • Phosphatidylcholines
  • Phosphatidylethanolamines
  • phosphatidylethanolamine