Effect of dietary supplementation with eicosapentaenoic acid in the treatment of atopic dermatitis

Br J Dermatol. 1987 Oct;117(4):463-9. doi: 10.1111/j.1365-2133.1987.tb04926.x.


The effects of a dietary supplement of n-3 fatty acids in patients with atopic dermatitis were investigated in a 12-week, double-blind study. The experimental group received 10 g of fish oil daily, of which about 1.8 g was eicosapentaenoic acid. This amount of eicosapentaenoic acid can be obtained from a daily intake of fat fish. The controls received an iso-energetic placebo supplement containing olive oil. Compliance was monitored by gas-chromatographic analysis of the fatty acid pattern in serum phospholipids. Results favoured the experimental group with regard to scale (P less than 0.05), itch (P less than 0.05) and overall subjective severity (P less than 0.02) as compared to the controls.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Clinical Trials as Topic
  • Dermatitis, Atopic / blood
  • Dermatitis, Atopic / drug therapy*
  • Diet
  • Docosahexaenoic Acids*
  • Double-Blind Method
  • Drug Combinations
  • Eicosapentaenoic Acid / administration & dosage
  • Eicosapentaenoic Acid / therapeutic use*
  • Fatty Acids, Unsaturated / therapeutic use
  • Female
  • Humans
  • Male
  • Middle Aged
  • Phospholipids / blood
  • Vitamin E / blood


  • Drug Combinations
  • Fatty Acids, Unsaturated
  • Maxepa
  • Phospholipids
  • Vitamin E
  • Docosahexaenoic Acids
  • Eicosapentaenoic Acid