Modulation of hepatic stellate cells and reversibility of hepatic fibrosis

Abstract

Hepatic fibrosis (HF) is the pathological component of a variety of chronic liver diseases. Hepatic stellate cells (HSC) are the main collagen-producing cells in the liver and their activation promotes HF. If HSC activation and proliferation can be inhibited, HF occurrence and development can theoretically be reduced and even reversed. Over the past ten years, a number of studies have addressed this process, and here we present a review of HSC modulation and HF reversal.

Keywords: Hepatic fibrosis; Hepatic stellate cells; Mechanism; Modulation; Reversibility.