Quantitative imaging biomarkers for dural sinus patterns in idiopathic intracranial hypertension

Brain Behav. 2017 Jan 3;7(2):e00613. doi: 10.1002/brb3.613. eCollection 2017 Feb.


Objective: To quantitatively characterize transverse dural sinuses (TS) on magnetic resonance venography (MRV) in patients with idiopathic intracranial hypertension (IIH), compared to healthy controls, using a computer assisted detection (CAD) method.

Materials and methods: We retrospectively analyzed MRV studies of 38 IIH patients and 30 controls, matched by age and gender. Data analysis was performed using a specially developed Matlab algorithm for vessel cross-sectional analysis. The cross-sectional area and shape measurements were evaluated in patients and controls.

Results: Mean, minimal, and maximal cross-sectional areas as well as volumetric parameters of the right and left transverse sinuses were significantly smaller in IIH patients than in controls (p < .005 for all). Idiopathic intracranial hypertension patients showed a narrowed segment in both TS, clustering near the junction with the sigmoid sinus. In 36% (right TS) and 43% (left TS), the stenosis extended to >50% of the entire length of the TS, i.e. the TS was hypoplastic. Narrower vessels tended to have a more triangular shape than did wider vessels.

Conclusion: Using CAD we precisely quantified TS stenosis and its severity in IIH patients by cross-sectional and volumetric analysis. This method can be used as an exact tool for investigating mechanisms of IIH development and response to treatment.

Keywords: MRI; idiopathic intracranial hypertension; neuro‐ophthalmology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers
  • Constriction, Pathologic / diagnostic imaging
  • Constriction, Pathologic / pathology
  • Cranial Sinuses / diagnostic imaging
  • Cranial Sinuses / pathology*
  • Female
  • Humans
  • Image Processing, Computer-Assisted / methods*
  • Magnetic Resonance Imaging / methods*
  • Male
  • Middle Aged
  • Phlebography
  • Pseudotumor Cerebri / diagnostic imaging
  • Pseudotumor Cerebri / pathology*
  • Retrospective Studies
  • Young Adult


  • Biomarkers