Aberrant growth of mossy fibers and enhanced kainic acid binding sites induced in rats by early hyperthyroidism

Brain Res. 1987 Oct 13;423(1-2):325-8. doi: 10.1016/0006-8993(87)90856-0.

Abstract

Early hyperthyroidism induces an aberrant growth of hippocampal mossy fibers both in the fascia dentata (supragranular layer) and in Ammon's horn (infrapyramidal layer of CA3). Using a quantitative autoradiographic method, we found a corresponding increase in kainic acid binding sites supporting previous observations of a very close association between mossy fiber terminals and kainic acid binding sites.

MeSH terms

  • Animals
  • Hippocampus / drug effects
  • Hippocampus / metabolism
  • Hippocampus / pathology*
  • Hyperthyroidism / metabolism
  • Hyperthyroidism / pathology*
  • Kainic Acid / metabolism*
  • Male
  • Pyramidal Tracts / metabolism
  • Pyramidal Tracts / pathology
  • Rats
  • Rats, Inbred Strains
  • Receptors, Kainic Acid
  • Receptors, Neurotransmitter / metabolism*
  • Thyroxine / pharmacology

Substances

  • Receptors, Kainic Acid
  • Receptors, Neurotransmitter
  • Thyroxine
  • Kainic Acid