An Unusual Cause of Myelopathy: Ochronotic Spondyloarthropathy With Positive HLA B27

Am J Phys Med Rehabil. 2017 Nov;96(11):e206-e209. doi: 10.1097/PHM.0000000000000727.


Ochronosis is a late developing complication of alkaptonuria, a black brownish pigment in the fibrous and cartilaginous tissues. Although most previous studies reported alkaptonuria and back pain due to ochronosis, thoracic myelopathy is an extremely rare complication. In this report, a paraparetic patient who has ochronotic spondiloarthropathy with the presence of HLA B27 antigen is described. He had low back and leg pain and morning stiffness for 5 yrs. Last year, these were followed by tingling, numbness, and weakness the in lower extremities and he was operated on with preliminary diagnosis of prolapsed disc herniation and cord compression. Surgery is suggested for disc herniations related to ochronotic spondyloarthropathy if it is necessary or neurologic symptoms are present. However, his pain and weakness have partially recovered after the operation. After medical and physical treatment, he showed clinically significant improvements. This case report demonstrates that the management of ochronosis needs a multidisciplinary approach with physiologic, neurologic, and psychologic effects and proper treatment may significantly improve functional outcomes in these patients.

Publication types

  • Case Reports

MeSH terms

  • HLA-B27 Antigen / blood*
  • Humans
  • Male
  • Middle Aged
  • Ochronosis / complications*
  • Ochronosis / immunology
  • Paraparesis / complications
  • Paraparesis / immunology
  • Spinal Cord Diseases / etiology*
  • Spinal Cord Diseases / immunology
  • Spondylarthropathies / complications*
  • Spondylarthropathies / immunology
  • Thoracic Vertebrae*


  • HLA-B27 Antigen