Liberal Versus Restrictive Transfusion Strategy in Critically Ill Oncologic Patients: The Transfusion Requirements in Critically Ill Oncologic Patients Randomized Controlled Trial

Crit Care Med. 2017 May;45(5):766-773. doi: 10.1097/CCM.0000000000002283.

Abstract

Objective: To assess whether a restrictive strategy of RBC transfusion reduces 28-day mortality when compared with a liberal strategy in cancer patients with septic shock.

Design: Single center, randomized, double-blind controlled trial.

Setting: Teaching hospital.

Patients: Adult cancer patients with septic shock in the first 6 hours of ICU admission.

Interventions: Patients were randomized to the liberal (hemoglobin threshold, < 9 g/dL) or to the restrictive strategy (hemoglobin threshold, < 7 g/dL) of RBC transfusion during ICU stay.

Measurements and main results: Patients were randomized to the liberal (n = 149) or to the restrictive transfusion strategy (n = 151) group. Patients in the liberal group received more RBC units than patients in the restrictive group (1 [0-3] vs 0 [0-2] unit; p < 0.001). At 28 days after randomization, mortality rate in the liberal group (primary endpoint of the study) was 45% (67 patients) versus 56% (84 patients) in the restrictive group (hazard ratio, 0.74; 95% CI, 0.53-1.04; p = 0.08) with no differences in ICU and hospital length of stay. At 90 days after randomization, mortality rate in the liberal group was lower (59% vs 70%) than in the restrictive group (hazard ratio, 0.72; 95% CI, 0.53-0.97; p = 0.03).

Conclusions: We observed a survival trend favoring a liberal transfusion strategy in patients with septic shock when compared with the restrictive strategy. These results went in the opposite direction of the a priori hypothesis and of other trials in the field and need to be confirmed.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Critical Care / methods
  • Critical Illness / mortality
  • Double-Blind Method
  • Erythrocyte Transfusion / methods*
  • Female
  • Hospitals, University / statistics & numerical data
  • Humans
  • Intensive Care Units / statistics & numerical data*
  • Length of Stay
  • Middle Aged
  • Neoplasms / epidemiology*
  • Proportional Hazards Models
  • Severity of Illness Index
  • Shock, Septic / epidemiology
  • Shock, Septic / mortality*
  • Shock, Septic / therapy*
  • Time Factors