Rebamipide ameliorates atherosclerosis by controlling lipid metabolism and inflammation

JooYeon Jhun; Jeong-Eun Kwon; Se-Young Kim; Jeong-Hee Jeong; Hyun Sik Na; Eun-Kyung Kim; Seung Hoon Lee; KyungAh Jung; Jun-Ki Min; Mi-La Cho

doi:10.1371/journal.pone.0171674

Rebamipide ameliorates atherosclerosis by controlling lipid metabolism and inflammation

PLoS One. 2017 Feb 27;12(2):e0171674. doi: 10.1371/journal.pone.0171674. eCollection 2017.

Authors

Affiliations

¹ The Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul, South Korea.
² IMPACT Biotech, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul, South Korea.
³ Bucheon St. Mary's Hospital, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Bucheon, South Korea.

Abstract

The oral administration of rebamipide decreased plaque formation in atherosclerotic lesions as well as the markers of metabolic disorder in ApoE-deficient mice with atherosclerosis. Pro-inflammatory cytokines were also suppressed by rebamapide. In addition, the population of Th17 was decreased, whereas Treg was increased in the spleen of rebamipide-treated ApoE deficient mice. Rebamipide also ameliorated the severity of obese arthritis and has the capability to reduce the development of atherosclerosis by controlling the balance between Th17 and Treg cells. Thus, rebamipide could be a therapeutic agent to improve the progression of inflammation in metabolic diseases.

MeSH terms

Alanine / analogs & derivatives*
Alanine / therapeutic use
Animals
Antioxidants / therapeutic use
Aorta / metabolism
Aorta / pathology
Apolipoproteins E / metabolism
Arthritis / chemically induced
Arthritis / drug therapy
Atherosclerosis / drug therapy*
Atherosclerosis / metabolism
Collagen / chemistry
Foam Cells / metabolism
Forkhead Transcription Factors / metabolism
Inflammation / metabolism*
Interleukin-17 / metabolism
Lipid Metabolism*
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Quinolones / therapeutic use*
T-Lymphocytes, Regulatory / metabolism
Th17 Cells / metabolism

Substances

Antioxidants
Apolipoproteins E
Forkhead Transcription Factors
Foxp3 protein, mouse
Il17a protein, mouse
Interleukin-17
Quinolones
Collagen
rebamipide
Alanine

Grants and funding

This study was supported by a grant of the Korean Health Technology R&D Project, Ministry for Health & Welfare, Republic of Korea (HI14C1851) and the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2015R1D1A1A01057072). The funders had no role in study design, data collection and analysis, decision to pubulish, or preparation of the manuscript.