Osteopathic Manipulative Treatment in the Management of Isaacs Syndrome

J Am Osteopath Assoc. 2017 Mar 1;117(3):194-198. doi: 10.7556/jaoa.2017.035.


Isaacs syndrome is a rare neuromuscular disorder characterized by chronic muscle stiffness, cramping, fasciculations, myokymia, and hyperhidrosis. Pathogenesis includes autoimmunity, paraneoplastic disorders, genetic predisposition, or toxin exposure. There is no known cure for Isaacs syndrome. This case report describes a patient who had been given the diagnosis of Isaacs syndrome and received osteopathic manipulative treatment to manage fascial and cranial dysfunctions and reduce nervous system hyperexcitability. Long-term decrease of myokymia and reduction of severity and frequency of exacerbations resulted.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Disease Progression
  • Electromyography / methods
  • Follow-Up Studies
  • Humans
  • Isaacs Syndrome / diagnosis*
  • Isaacs Syndrome / rehabilitation*
  • Male
  • Manipulation, Osteopathic / methods*
  • Middle Aged
  • Rare Diseases
  • Risk Assessment
  • Severity of Illness Index
  • Time Factors
  • Treatment Outcome