Associations of hyperglycemia and insulin resistance with biomarkers of endothelial dysfunction in Hispanic/Latino youths: Results from the Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth)

J Diabetes Complications. 2017 May;31(5):836-842. doi: 10.1016/j.jdiacomp.2017.01.019. Epub 2017 Feb 9.

Abstract

Aims: We hypothesized that Hispanic/Latino youth at high risk for diabetes would have elevated biomarkers of endothelial dysfunction.

Methods: Among 1316 children 8-16years old from the Study of Latino Youth (SOL Youth), we used Poisson regression to obtain prevalence ratios (PRs) and 95% CIs for the cross-sectional association of quartiles of fasting glucose, HbA1c, and insulin resistance with E-selectin and plasminogen activator inhibitor-1 (PAI-1) levels above the median (≥48.1 and ≥2.02ng/mL, respectively).

Results: Levels of E-selectin and PAI-1 were higher in children who were obese or had higher levels of hs-CRP (p<0.05). Insulin resistance was independently associated with higher levels of PAI-1 (adjusted PR and 95% CI for the highest versus lowest quartile (Q4 vs Q1): 2.25 [1.64, 3.09]). We found stronger evidence of associations of insulin resistance with higher levels of PAI-1 among boys as compared with girls (p-interaction = 0.10).

Conclusions: Insulin resistance was associated with endothelial dysfunction, as measured by higher levels of PAI-1, in Hispanic/Latino youth. These biomarkers may be useful in risk stratification and prediction of diabetes and cardiovascular disease in high-risk youth.

Keywords: Adolescents/children; E-selectin; Hispanics; Hyyperglycemia; Insulin resistance; Plasminogen activator inhibitor-1.

Publication types

  • Multicenter Study
  • Observational Study

MeSH terms

  • Adolescent
  • Biomarkers / blood
  • Cardiovascular Diseases / complications
  • Cardiovascular Diseases / epidemiology
  • Cardiovascular Diseases / ethnology
  • Child
  • Cohort Studies
  • Cross-Sectional Studies
  • Diabetic Angiopathies / complications
  • Diabetic Angiopathies / epidemiology
  • Diabetic Angiopathies / ethnology
  • Diabetic Cardiomyopathies / complications
  • Diabetic Cardiomyopathies / epidemiology
  • Diabetic Cardiomyopathies / ethnology
  • Endothelium, Vascular / physiopathology*
  • Female
  • Health Surveys
  • Hispanic or Latino
  • Humans
  • Hyperglycemia / complications*
  • Hyperglycemia / epidemiology
  • Hyperglycemia / metabolism
  • Hyperglycemia / physiopathology
  • Insulin Resistance*
  • Male
  • Poisson Distribution
  • Prediabetic State / complications*
  • Prediabetic State / ethnology
  • Prevalence
  • Risk
  • United States / epidemiology
  • Vascular Diseases / complications*
  • Vascular Diseases / epidemiology
  • Vascular Diseases / metabolism
  • Vascular Diseases / physiopathology

Substances

  • Biomarkers